Pituitary Adenoma Nitroproteomics: Current Status and Perspectives

نویسندگان

  • Xianquan Zhan
  • Xiaowei Wang
  • Dominic M. Desiderio
چکیده

Oxidative stress is extensively associated with tumorigenesis. A series of studies on stable tyrosine nitration as a marker of oxidative damage were performed in human pituitary and adenoma. This paper reviews published research on the mass spectrometry characteristics of nitropeptides and nitroproteomics of pituitary controls and adenomas. The methodology used for nitroproteomics, the current status of human pituitary nitroproteomics studies, and the future perspectives are reviewed. Enrichment of those low-abundance endogenous nitroproteins from human tissues or body fluid samples is the first important step for nitroproteomics studies. Mass spectrometry is the essential approach to determine the amino acid sequence and locate the nitrotyrosine sites. Bioinformatics analyses, including protein domain and motif analyses, are needed to locate the nitrotyrosine site within the corresponding protein domains/motifs. Systems biology techniques, including pathway analysis, are necessary to discover signaling pathway networks involving nitroproteins from the systematically global point of view. Future quantitative nitroproteomics will discover pituitary adenoma-specific nitroprotein(s). Structural biology techniques such as X-ray crystallography analysis will solidly clarify the effects of tyrosine nitration on structure and functions of a protein. Those studies will eventually address the mechanisms and biological functions of tyrosine nitration in pituitary tumorigenesis and will discover nitroprotein biomarkers for pituitary adenomas and targets for drug design for pituitary adenoma therapy.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

بررسی ایمونوهیستوشیمی آدنوم‌های هیپوفیز و مقایسه آن با تظاهرات بالینی در 102 نمونه بلوک پارافینی

Routine classification of pituitary adenomas is not appropriate for diagnosis of adenoma type and in some cases there is inconcordance between clinical presentation and histological type of adenoma. The aim of this study was to determine the type of adenoma secretion based on immunohistochemical staining. 102 paraffin blocked specimens of pituitary adenoma were stained with hormone ...

متن کامل

Microscopic Transsphenoidal Surgery for Pituitary Adenomas in Children and Adolescents

Background & Aim: We described the presentation, management and subsequent treatment outcomes of children and adolescents diagnosed with a pituitary adenoma in a joint neuroendocrine setting followed up by a single service as well as assessing long-term outcomes in terms of endocrine status and neurology symptoms. Methods & Materials/Patients: A total of 21 participants with histologically v...

متن کامل

بررسی خصوصیات دموگرافیک و کیفیت زندگی بیماران مبتلا به آدنوم هیپوفیز مراجعه‌کننده به یک درمانگاه تخصصی مرجع در تهران در سال 1390

Background and Objective: Pituitary adenoma (PA) is one of the most common intracranial tumors. In recent years, some research has been done on patients with PA. Given the lack of similar research in Iran, this study was conducted to assess the demographic characteristics and the quality of life among Iranian patients with PA. Materials and Methods: This study was a cross- sectional- de...

متن کامل

Coexisting Pituitary Adenoma and Suprasellar Meningioma: A Coincidence or Causation Effect? Report of Two Cases and Review of Literature

Background and Importance: The coexistence of pituitary adenoma and another type of brain tumor is a very rare clinical scenario. Even though such a presentation can be an incidental event but the possible pathogenesis of coexistence of different lesions in the sella and suprasellar region has not yet been elucidated. Case Presentation: Two cases of concomitant sellar and suprasellar region ...

متن کامل

Case Report: Co-Occurrence of Pituitary Adenoma with Suprasellar and Olfactory Groove Meningiomas

Introduction: The co-existence of pituitary adenoma and meningioma is extremely rare. It is even rarer in patients with no previous known risk factors for either tumour. Here, we present a case of synchronous non-functioning pituitary adenoma with suprasellar and olfactory groove meningiomas in a patient without previous irradiation. Methods: The tumours were diagnosed on MRI in the 65-year-ol...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2013  شماره 

صفحات  -

تاریخ انتشار 2013